Japan finds a tacit agreement between kinesin and dynein

Japan finds a tacit agreement between kinesin and dynein. Researchers at Osaka City University in Japan found that there is a "meeting" between kinesin and dynein related to intracellular material transport. Its protein "shelf" is loaded with dynein, which helps dynein to complete the delivery task. According to Japan's "Yomiuri Shimbun" reported on December 27, microtubules extending radially from the center to the surroundings are distributed in the cells. The microtubules are channels for transporting proteins and other substances necessary for life. It is the kinesin and dynein that are responsible for transportation. Both of these proteins are "driving" in one direction, but the kinesin is only transported from the center of the cell to the outside of the cell, which ends the mission, while the dynein can repeatedly perform the transport task. However, previous studies have shown that dynein can only move toward the center of the cell, and it has been a mystery how it accomplishes the transport task in the opposite direction. Researchers such as Shinji Hiroki, a professor at Osaka City University, found in research that a protein “shelf” on kinesin is the key to solving the problem. When dynein runs to the end of the "line", kinesin will use the "shelf" to carry dynein back to the outside of the cell. In addition, this "shelf" also carries a variety of other proteins and organelles. The researchers pointed out that if the intracellular transport of substances cannot be carried out smoothly, it may cause neurodegenerative diseases and cancer. They plan to further study the specific mechanism of the coordinated operation of kinesin and dynein in the future to help solve the above diseases Pathogenesis.

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