Discovered a gene that can cause multiple cancers

The research team of the Japanese Autonomous Medical University reported on the 5th online version of the "Journal of the National Academy of Sciences" that they have discovered a gene that can cause breast cancer, skin malignant melanoma and other cancers. This discovery will promote research and development. A new anti-cancer drug targeting this gene.

The research team used an independently developed method to observe the cancer cells of a fibrosarcoma patient in their 30s and found that the RAC1 gene mutation will play a role as a cancer gene and become the main cause of fibrosarcoma.

In addition to fibrosarcoma, the research team also found mutations in the RAC1 gene and genes close to it in six types of cancer, including malignant melanoma, some breast cancers, and pancreatic cancer. About 5% of patients with malignant melanoma and about 3% of breast cancer patients have found this variant gene.

The research team also confirmed in animal experiments that tumors appeared in the sites where the mutant genes were implanted in the rats.

The research team member and professor at the Autonomous Medical University Hirano Hakano pointed out: "If you can develop a drug that suppresses the role of this variant gene, and a low-cost diagnostic method for detecting this variant gene from the patient's cancer cells, then a kind of Effective treatments for multiple cancers are possible. "

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