Sun Yat-sen University discovers new mechanism of DNA mutations regulating chromatin structure

<p> It was learned from Sun Yat-sen University that the team led by Professor He Xionglei of the School of Life Sciences has made important progress in how chromatin structure regulates DNA mutations. The relevant results were published in the March 9 issue of Science. This is the first time in the past ten years that Sun Yat-sen University has published a paper in the journal Science as the first author.

According to researchers, mutations are the basis of biological evolution and the main cause of disease. Human genetic material DNA is composed of four bases, A, T, C and G. Among them, the C base is easily mutated into the analog base U, and causes a series of chain reactions, thus causing mutations in human genetic material. Statistics show that 1/4 of human genetic diseases are caused by the above mutations. Therefore, whether or how such mutations are regulated in cells is a question of great research value.

He Xionglei team found that the nucleosome structure in eukaryotic cells can inhibit the hydrolytic deamination of cytosine C, thereby reducing the mutation of cytosine C to thymine T. This discovery reveals the regulation mechanism of chromatin structure on the genetic core event, DNA mutation, provides an important reference value for the study and prevention of tumorigenesis, and has a guiding role in understanding the genome structure and biological evolution of nuclear organisms.

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