In a research report published in the international journal Nature Genetics, researchers from institutions such as the University of Amsterdam first discovered seven risk genes related to insomnia through research, and related research or the study of the biology of inducing human insomnia The mechanism provides ideas; in addition, the researchers also said that insomnia may not be a purely mental illness as people often say.
Insomnia may be the most common health complaint we face in daily life. Even after treatment, lack of sleep has been plaguing people's health. In this study, researchers have discovered risk genes associated with insomnia, which reveals The cause of inducing insomnia is very important. Researcher Van Someren believes that the study understands insomnia at the level of "communication" between neurons, and we hope to develop new therapies for insomnia later.
Few studies have been able to clarify the causes and risk factors of insomnia. In this study, researchers studied tissue from 113,006 individuals and found seven risk genes associated with insomnia. These genes are involved in cellular gene transcription. The regulatory process and the role of exocytosis play a key role. The researchers said that one of the genes, called MEIS1, was directly related to two sleep disorders in previous studies, such as periodic limb movements of sleep (PLMS) and sleep apathy (RLS). After a joint study with researchers at the Helmholtz Munich Center in Germany, the researchers concluded that genetic mutations in the genes seem to trigger the above three sleep disorders (including insomnia), with the main features of PLMS and RLS being restless. The main feature of insomnia is a disturbing flow of brain consciousness.
The researchers also found strong genetic overlap between other features, such as anxiety disorders, depression, neuroticism, and lower subjective well-being. Of course, this is also an interesting research finding because these characteristics also tend to be insomnia. The disease is closely related. At the same time, the researchers also studied the importance of the same genetic mutations for men and women. The results show that some genetic mutations are different, which means that in some cases, different biological mechanisms are more likely to induce Insomnia in men and women; the researchers also clarified the difference in the prevalence of insomnia between men and women, including people over the age of 50, while 33% of women said they experienced insomnia, while the proportion of men was 24 %.
Researchers can now find risk genes for disease-inducing by diagnosing and DNA-tracking studies of thousands of individuals. The UK's biological sample bank does not contain information related to the diagnosis of insomnia, but researchers can ask participants if they find out. Sleep is difficult or has a good sleep habit; by making full use of the information from the Dutch sleep database, the British biological sample library is also the first to analyze the characteristics of insomnia individuals, of course, later researchers hope to go deeper Research to develop new targeted therapies for the treatment of insomnia.
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